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Switchable Lipids: From Conformational Switch to Macroscopic Changes in Lipid Vesicles by Huu Trong Phan; Victor Passos Gibson; Aurore Guédin; Emmanuel Ibarboure; Nadia El Mammeri; Axelle Grélard; Jean-François Le Meins; Erick J. Dufourc; Antoine Loquet; Suzanne Giasson; Jeanne Leblond Chain is a Materials Science article available to read on EtoBox.
What is Switchable Lipids: From Conformational Switch to Macroscopic Changes in Lipid Vesicles about?
It has been shown that the use of conformationally pH-switchable lipids can drastically enhance the cytosolic drug delivery of lipid vesicles. Understanding the process by which the pH-switchable lipids disturb the lipid assembly of nanoparticles and trigger the cargo release is crucial to optimize the rational design of pH-switchable lipids. Here, we gather morphological observations (FF-SEM, Cryo-TEM, AFM, confocal microscopy), physicochemical characterization (DLS, ELS), as well as phase behavior studies (DSC, 2 H NMR, Langmuir isotherm, and MAS NMR) to propose a mechanism of pH-triggered membrane destabilization. We demonstrate that the switchable lipids are homogeneously incorporated with other co-lipids (DSPC, cholesterol, and DSPE-PEG 2000 ) and promote a liquid-ordered phase insensitive to temperature variation. Upon acidification, the protonation of the switchable lipids triggers a conformational switch altering the self-assembly properties of lipid nanoparticles. These modifications do not lead to a phase separation of the lipid membrane; however, they cause fluctuations and local defects, which result in morphological changes of the lipid vesicles. These changes are prop
Who reads Switchable Lipids: From Conformational Switch to Macroscopic Changes in Lipid Vesicles?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Huu Trong Phan; Victor Passos Gibson; Aurore Guédin; Emmanuel Ibarboure; Nadia El Mammeri; Axelle Grélard; Jean-François Le Meins; Erick J. Dufourc; Antoine Loquet; Suzanne Giasson; Jeanne Leblond Chain
- Publisher
- American Chemical Society (ACS)
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)