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Molecules 31 00766 by Kamila Środa-Pomianek is a document available to read on EtoBox.
The study investigates the co-inhibition of Kv1.3 channel activity by isobavachalcone (IBC) and non-prenylated chalcones in Jurkat T cancer cells, revealing that IBC causes almost complete and irreversible inhibition, while the non-prenylated chalcones exhibit reversible effects. The inhibitory effects of IBC are significantly enhanced when combined with statins simvastatin and mevastatin, suggesting potential clinical applications in cancer treatment. The results indicate that both chalcones and statins co
- Author
- Kamila Środa-Pomianek
- Language
- EN