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Can I read 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements on EtoBox?
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements by Jeffrey J. Hale; Richard J. Budhu; Sander G. Mills; Malcolm MacCoss; Lorraine Malkowitz; Salvatore Siciliano; Sandra L. Gould; Julie A. DeMartino; Martin S. Springer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements about?
A series of 1,3,4-trisubstituted pyrrolidines was discovered to have the ability to displace [ 125 I]-MIP-1a from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the pyrrolidine.
Who reads 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jeffrey J. Hale; Richard J. Budhu; Sander G. Mills; Malcolm MacCoss; Lorraine Malkowitz; Salvatore Siciliano; Sandra L. Gould; Julie A. DeMartino; Martin S. Springer
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)