Can I read Variola Virus Immune Evasion Proteins on EtoBox?
Variola Virus Immune Evasion Proteins by Lance R Dunlop; Katherine A Oehlberg; Jeremy J Reid; Dilek Avci; Ariella M Rosengard is a Medicine article available to read on EtoBox.
What is Variola Virus Immune Evasion Proteins about?
Variola virus, the causative agent of smallpox, encodes approximately 200 proteins. Over 80 of these proteins are located in the terminal regions of the genome, where proteins associated with host immune evasion are encoded. To date, only two variola proteins have been characterized. Both are located in the terminal regions and demonstrate immunoregulatory functions. One protein, the smallpox inhibitor of complement enzymes (SPICE), is homologous to a vaccinia virus virulence factor, the vaccinia virus complement-control protein (VCP), which has been found experimentally to be expressed early in the course of vaccinia infection. Both SPICE and VCP are similar in structure and function to the family of mammalian complement regulatory proteins, which function to prevent inadvertent injury to adjacent cells and tissues during complement activation. The second variola protein is the variola virus high-affinity secreted chemokine-binding protein type II (CKBP-II, CBP-II, vCCI), which binds CC-chemokine receptors. The vaccinia homologue of CKBP-II is secreted both early and late in infection. CKBP-II proteins are highly conserved among orthopoxviruses, sharing approximately 85% homology,
Who reads Variola Virus Immune Evasion Proteins?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lance R Dunlop; Katherine A Oehlberg; Jeremy J Reid; Dilek Avci; Ariella M Rosengard
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Life Sciences)