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Abstract Antimicrobial resistance (AMR) is one of the most worrying health problems worldwide, antimicrobial research with reference to medicinal plants is a growing domain, likewise the synergism between plant extract and antibiotics. The present study seeks to propose and develop uses a simple, safe, less time consuming, cost-effective, and eco-friendly strategic synthetic methods to overcome antibiotic resistance in bacteria using ethnopharmacological approach with conventional antibiotics. Concentrated sulphuric acid and 10% sodium hydroxide were used in combinatorial synthesis of Calotropis procera extract with Amoxicillin and Ampicillin.to validate the positive results obtain in stage one,Piliostigma reticulatum extract was combine with 100 μg/mL of azithromycin and again with 100 μg/ml of ampicillin with 0.1 mL, 0.2 mL and 0.3 mL of the acid to validate and a different bacteria strain was also introduced. Higher inhibitions zone were observed at 16.7 mm for salmonella spp, 16.4 mm shigella spp, 16.8 mm S. aureus, 21.3 mm E.coli and 22.4 mm streptococusat situations where antibiotics inhibitions zones was 0 mm. The results obtained shows that acid combinatorial synthesis of a

Author

Mathew Gideon; Zakari Ladan

Published

2022

Language

EN