Can I read Long‐term Botulinum Toxin Efficacy, Safety, and Immunogenicity on EtoBox?

Long‐term Botulinum Toxin Efficacy, Safety, and Immunogenicity by Nicte I. Mejia; Kevin Dat Vuong; Joseph Jankovic is a Medicine article available to read on EtoBox.

What is Long‐term Botulinum Toxin Efficacy, Safety, and Immunogenicity about?

## Abstract To determine the long‐term efficacy of botulinum toxin (BTX) treatments, we analyzed longitudinal follow‐up data on 45 patients (32 women; mean age, 68.8 years) currently followed in the Baylor College of Medicine Movement Disorders Clinic, who have received BTX treatments continuously for at least 12 years (mean 15.8 ± 1.5 years). Their mean response rating after the last injection, based one a previously described scale 0‐to‐4 scale (0 = no effect; 4 = marked improvement) was 3.7 ± 0.6 and the mean total duration of response was 15.4 ± 3.4 weeks. Although the latency and total duration of the response to treatment have not changed over time, the peak duration of response (__P__ < 0.005) and dose per visit (__P__ < 0.0001) have increased since the initial visit. Furthermore, global rating (__P__ < 0.02) and peak effect (__P__ < 0.05) have improved. In total, 20 adverse events occurred in 16 of 45 (35.6%) patients after their initial visit and 11 adverse events in 10 of 45 (22.2%) patients at their most recent injection visit. Antibody (Ab) testing was carried out in 22 patients due to nonresponsiveness; blocking Abs were confirmed by the mouse protection assay in 4 of

Who reads Long‐term Botulinum Toxin Efficacy, Safety, and Immunogenicity?

Author

Nicte I. Mejia; Kevin Dat Vuong; Joseph Jankovic

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2005

Language

EN

Field

Medicine (Health Sciences)