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Can I read Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2 on EtoBox?
Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2 by Fabienne De Bilbao; Ernesto Guarin; Patrick Nef; Philippe Vallet; Panteleimon Giannakopoulos; Michel Dubois-Dauphin is a Neuroscience article available to read on EtoBox.
What is Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2 about?
## Abstract Previous studies have suggested that various apoptotic‐related proteins could be involved in the death process induced by cerebral ischaemia. In order to further clarify their role and examine how the anti‐apoptotic protein Bcl‐2 could influence this process, the time‐course of mRNA expression of various cell death genes was studied from 1 to 14 days following permanent occlusion of the middle cerebral artery in wild‐type (WT) and Bcl‐2 transgenic mice, within and outside the area of infarction. No differences of the infarct sizes were observed between the two groups of mice, showing that the extent of neuronal injury could not have been lowered by the Bcl‐2 transgene. Seven days after the ischaemic insult, the mRNA expression of the cell death gene effector cpp32 was dramatically upregulated in the penumbra of WT and Bcl‐2 transgenic mice. Interestingly, the cpp32 transcript was markedly induced from 3 days in the ipsilateral thalamus of the two groups of mice. However, apoptotic bodies were observed in the thalamic field of WT but not transgenic mice. This suggests that cpp32 mRNA may be induced in an attempt to kill the injured cells and, in contrast to the penumbra,
Who reads Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Fabienne De Bilbao; Ernesto Guarin; Patrick Nef; Philippe Vallet; Panteleimon Giannakopoulos; Michel Dubois-Dauphin
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2000
- Language
- EN
- Field
- Neuroscience (Life Sciences)