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Neurocognitive Dysfunction and Smaller Brain Volumes in Adolescents and Adults With a Fontan Circulation by Charlotte E. Verrall; Joseph Y.M. Yang; Jian Chen; Adrian Schembri; Yves d’Udekem; Diana Zannino; Nadine A. Kasparian; Karin du Plessis; Stuart M. Grieve; Thomas Welton; Belinda Barton; Thomas L. Gentles; David S. Celermajer; Chantal Attard; Kathryn Rice; Julian Ayer; Simone Mandelstam; David S. Winlaw; Mark T. Mackay; Rachael Cordina is a Medicine article available to read on EtoBox.
What is Neurocognitive Dysfunction and Smaller Brain Volumes in Adolescents and Adults With a Fontan Circulation about?
## Background: Neurocognitive outcomes beyond childhood in people with a Fontan circulation are not well defined. This study aimed to investigate neurocognitive functioning in adolescents and adults with a Fontan circulation and associations with structural brain injury, brain volumetry, and postnatal clinical factors. ## Methods: In a binational study, participants with a Fontan circulation without a preexisting major neurological disability were prospectively recruited from the Australia and New Zealand Fontan Registry. Neurocognitive function was assessed by using Cogstate software in 107 participants with a Fontan circulation and compared with control groups with transposition of the great arteries (n=50) and a normal circulation (n=41). Brain MRI with volumetric analysis was performed in the participants with a Fontan circulation and compared with healthy control data from the ABIDE I and II (Autism Brain Imaging Data Exchange) and PING (Pediatric Imaging, Neurocognition, and Genetics) data repositories. Clinical data were retrospectively collected. ## Results: Of the participants with a Fontan circulation who had a neurocognitive assessment, 55% were male and the mean age was
Who reads Neurocognitive Dysfunction and Smaller Brain Volumes in Adolescents and Adults With a Fontan Circulation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Charlotte E. Verrall; Joseph Y.M. Yang; Jian Chen; Adrian Schembri; Yves d’Udekem; Diana Zannino; Nadine A. Kasparian; Karin du Plessis; Stuart M. Grieve; Thomas Welton; Belinda Barton; Thomas L. Gentles; David S. Celermajer; Chantal Attard; Kathryn Rice; Julian Ayer; Simone Mandelstam; David S. Winlaw; Mark T. Mackay; Rachael Cordina
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)