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The document discusses the development and validation of an in vitro GastroIntestinal dialysis model with a colon phase (GIDM-colon) to study the availability and colonic metabolization of polyphenolic compounds, specifically chlorogenic acid. The model simulates gastrointestinal digestion and absorption, allowing for the prediction of complex secondary metabolite availability and their bioactivity. Validation results indicate that the model effectively mimics in vivo conditions, demonstrating good recovery

Author

frenlyw

Language

EN