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What is Mutant p53: Transcriptional Regulation Insights about?

The study investigates the role of mutant p53 (mutp53) as a transcriptional co-factor that binds to G-rich regulatory regions of active genes, contributing to transcriptional plasticity. It identifies that mutp53 preferentially binds to G/C-rich DNA around transcription start sites, often overlapping with CpG islands and G-quadruplex motifs, which are associated with cancer-relevant genes. The findings suggest that mutp53

Author

subkatie7

Language

EN