Opening book details…
Can I read Drug Dual-release Matrix Proprieties and the Correlations with Nanostructure Aggregation Kinetics for Siloxane-polyether/hydrogel Nanocomposites† on EtoBox?
Drug Dual-release Matrix Proprieties and the Correlations with Nanostructure Aggregation Kinetics for Siloxane-polyether/hydrogel Nanocomposites† by Mac-Kedson Medeiros Salviano Santos; Marcelo Henrique Sousa; Juliano Alexandre Chaker is a Materials Science article available to read on EtoBox.
What is Drug Dual-release Matrix Proprieties and the Correlations with Nanostructure Aggregation Kinetics for Siloxane-polyether/hydrogel Nanocomposites† about?
The influence of hydrogels on the nanostructural formation of siloxane-polyether nanocomposites was examined. The nanostructure was studied with small-angle X-ray scattering (SAXS) to determine the siloxane nanostructure aggregation mechanisms. The interactions between matrix and drug were examined by infrared spectroscopy to verify the compatibility of the drug with the matrix. For __in vitro__ release tests Piroxicam was used as a model molecule. The variation of the different types of hydrogels, bis-acrylamide (BIS), poly(acrylamide-__co__-acrylic acid) (PAM) and polyvinylpyrrolidone (PVP) can modify the drug release profiles. The release behaviour was determined to be composed of two concomitant release mechanisms. The first is in the early stages of drug release, governed by erosion, diffusion and swelling and the second, in advanced stages of release, typical of diffusion through pores. These dependencies were found to be correlated to the physical and chemical properties of the nanocomposites, including the interactions disturbing polycondensation formation. The release rate depends on intramolecular matrix–matrix and intermolecular drug–matrix interactions, as well as a cry
Who reads Drug Dual-release Matrix Proprieties and the Correlations with Nanostructure Aggregation Kinetics for Siloxane-polyether/hydrogel Nanocomposites†?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Mac-Kedson Medeiros Salviano Santos; Marcelo Henrique Sousa; Juliano Alexandre Chaker
- Published
- 2021
- Language
- EN
- Field
- Materials Science (Physical Sciences)