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The Characteristics, Biodistribution, Magnetic Resonance Imaging and Biodegradability of Superparamagnetic Core–shell Nanoparticles by Po-Wei Lee; Sheng-Hsiang Hsu; Jiun-Jie Wang; Jin-Sheng Tsai; Kun-Ju Lin; Shiaw-Pyng Wey; Fu-Rong Chen; Chih-Huang Lai; Tzu-Chen Yen; Hsing-Wen Sung is a Engineering article available to read on EtoBox.
What is The Characteristics, Biodistribution, Magnetic Resonance Imaging and Biodegradability of Superparamagnetic Core–shell Nanoparticles about?
An efficient contrast agent for magnetic resonance imaging (MRI) is essential to enhance the detection and characterization of lesions within the body. In this study, we described the development of biodegradable nanoparticles with a core-shell structure to formulate superparamagnetic iron oxide (CSNP-SPIO) for MRI. The developed nanoparticles were composed of a hydrophobic PLGA core and a positivelycharged glycol chitosan shell. The results obtained by transmission electron microscopy, energy dispersive X-ray analysis, electron energy loss spectroscopy, and X-ray diffraction measurement confirmed that the prepared nanoparticles had a core-shell structure with SPIO in their core area. No aggregation of nanoparticles was observed during storage in water, as a result of the electrostatic repulsion between the positively-charged nanoparticles. The magnetic properties of nanoparticles were examined by a vibrating sample magnetometer and a superconducting quantum interference device; the results showed that the superparamagnetism of SPIO was preserved after the CSNP-SPIO formulation. In tracking their cellular internalization pathway, we found that CSNP-SPIO accumulated in lysosomes. In
Who reads The Characteristics, Biodistribution, Magnetic Resonance Imaging and Biodegradability of Superparamagnetic Core–shell Nanoparticles?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Po-Wei Lee; Sheng-Hsiang Hsu; Jiun-Jie Wang; Jin-Sheng Tsai; Kun-Ju Lin; Shiaw-Pyng Wey; Fu-Rong Chen; Chih-Huang Lai; Tzu-Chen Yen; Hsing-Wen Sung
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2010
- Language
- EN
- Field
- Engineering (Physical Sciences)