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Can I read The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production on EtoBox?
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production by Mark Sabat; John C. VanRens; Michael P. Clark; Todd A. Brugel; Jennifer Maier; Roger G. Bookland; Matthew J. Laufersweiler; Steven K. Laughlin; Adam Golebiowski; Biswanath De; Lily C. Hsieh; Richard L. Walter; Marlene J. Mekel; Michael J. Janusz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production about?
A series of C-2, C-8, and N-9 trisubstituted purine based inhibitors of TNF-a production are described. The most potent analogs showed low nanomolar activity against LPS-induced TNF-a production in a THP-1 cell based assay. The SAR of the series was optimized with the aid of X-ray co-crystal structures of these inhibitors bound with mutated p38 (mp38).
Who reads The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mark Sabat; John C. VanRens; Michael P. Clark; Todd A. Brugel; Jennifer Maier; Roger G. Bookland; Matthew J. Laufersweiler; Steven K. Laughlin; Adam Golebiowski; Biswanath De; Lily C. Hsieh; Richard L. Walter; Marlene J. Mekel; Michael J. Janusz
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)