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Pulmonary Function Abnormalities in Children Treated with Whole Lung Irradiation by Daniel J. Weiner; Amit Maity; Claire A. Carlson; Jill P. Ginsberg is a Medicine article available to read on EtoBox.

What is Pulmonary Function Abnormalities in Children Treated with Whole Lung Irradiation about?

## Abstract ## Background We sought to determine the prevalence of abnormal pulmonary function tests (PFTs) in a cohort of children who had received whole lung irradiation (WLI) for treatment of metastatic disease. ## Procedure This was a retrospective (1988–2003) chart review that included all children treated at our institution with WLI who had undergone PFT. Data abstracted included oncologic diagnosis, radiation dose and fractionation, spirometry (FVC, FEV~1~, FEV~1~/FVC, FEF~25%–75%~), plethysmography (TLC, FRC, RV, RV/TLC), diffusing capacity (DLCO), and respiratory muscle strength (MIP, MEP). PFTs were normalized according to standard deviation (Z) scores. ## Results Thirty patients were identified who had one or more PFT. The incidence of mild, moderate, or severe reductions in FEV~1~ was 30%, 10%, and 10%, respectively, with 50% having normal FEV~1~. Seventeen percent of patients had mild reduction in total lung capacity (TLC), while 13% and 30% had moderate or severe reductions. Thirty‐eight percent had mild reductions in diffusing capacity, while 29% and 14% had moderate or severe reductions. ## Conclusions Pulmonary function abnormalities were common in this cohort of c

Who reads Pulmonary Function Abnormalities in Children Treated with Whole Lung Irradiation?

Author

Daniel J. Weiner; Amit Maity; Claire A. Carlson; Jill P. Ginsberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2005

Language

EN

Field

Medicine (Health Sciences)