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ASO Author Reflections: Intensified Neoadjuvant Chemoradiotherapy Followed by Esophagectomy in Esophageal Cancer by Boers, Jorianne; de Groot, Jan Willem B. is a Medicine article available to read on EtoBox.

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## PAST Neoadjuvant chemoradiotherapy for resectable esophageal cancer has become standard practice, based on the Dutch CROSS study. 1,2 This therapy consists of five cycles of carboplatin/paclitaxel with concurrent radiotherapy (41.4 Gy); however, the role of intensified neoadjuvant chemoradiotherapy with a higher dose of both chemotherapy and radiotherapy is unclear. ## PRESENT We analyzed a cohort of 176 patients with potentially resectable esophageal cancer treated with intensified neoadjuvant chemoradiotherapy (six cycles of carboplatin/paclitaxel with concurrent radiotherapy [50.4 Gy]), 3 and found that our intensified regimen was feasible but adverse events occurred frequently. Although high rates of pathological complete responses were seen, a survival benefit, compared with conventional neoadjuvant chemoradiotherapy, seems lacking. ## FUTURE Due to the retrospective nature of our study design, a randomized trial is needed to identify the added value of intensified neoadjuvant chemoradiotherapy for resectable esophageal cancer. Until then, we advise against intensification of neoadjuvant therapy.

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Author

Boers, Jorianne; de Groot, Jan Willem B.

Publisher

Springer; Springer - Society of Surgical Oncology; Springer New York LLC; Springer Science and Business Media LLC (ISSN 1068-9265)

Published

2020

Language

EN

Field

Medicine (Health Sciences)