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Ethnicity and incidence of congenital hypothyroidism in the capital of Macedonia by Violeta Anastasovska; Mirjana Kocova is a Medicine article available to read on EtoBox.

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Background: Congenital hypothyroidism (CH) is a common and preventable cause of intellectual disability for which early diagnosis is difficult without newborn screening. Genetic and environmental factors, race, ethnicity, sex, and pregnancy outcomes were noted as risk factors. In the study we aimed to determine the incidence of CH among different ethnic groups in the capital of Macedoina -a multiethnic city. Methods: A 14-year retrospective cohort analysis was performed on 121,507 newborns in the capital of Macedonia, Skopje, screened for whole-blood thyroid-stimulating hormone (TSH), in dry blood spots collected 48-72 h after birth, during the period 2002-2015. A TSH value of 15 mIU/L was used as cutoff point until 2010 and 10 mIU/L thereafter. Results: Primary CH was detected in 46 newborns (female to male ratio 1.3) with overall incidence of 3.8/10,000 (1/2641). The incidence of primary CH was significantly increased after lowering the TSH cutoff value (p = 0.038), primarily due to detected neonates with transient CH for this period. Ethnic differences in the incidence of primary CH were detected. CH incidence among Roma neonates (6.7/10,000) was significantly higher (p < 0.05)

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Author

Violeta Anastasovska; Mirjana Kocova

Publisher

Walter de Gruyter GmbH

Published

2016

Language

EN

Field

Medicine (Health Sciences)