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Decreased Expression of Keratinocyte β1 Integrins in Chronically Sun-exposed Skin in Vivo by S. Bosset; M. Bonnet-Duquennoy; P. Barré; A. Chalon; K. Lazou; R. Kurfurst; F. Bonté; S. Schnébert; F. Disant; B. Le Varlet; J.F. Nicolas is a Medicine article available to read on EtoBox.
What is Decreased Expression of Keratinocyte β1 Integrins in Chronically Sun-exposed Skin in Vivo about?
## Background: Chronic exposure to ultraviolet (uv) radiation induces changes in the skin structure which are mostly found in the superficial dermis and at the dermal-epidermal junction. keratinocytes and fibroblasts contribute both to the synthesis and to the degradation of the molecules important for the integrity of this skin site. while several studies have reported on alterations of dermal components and of the functions of fibroblasts in vivo and in vitro after uv exposure, recent data suggested that keratinocytes could be the main skin cell type involved in the photoageing process. ## Objectives: In this study, we analysed the expression of two keratinocyte molecules namely, beta1 integrin (a proliferation marker) and involucrin (a differentiation marker) in sun-exposed and sun-protected facial skin of 16 healthy patients undergoing facial lifting. ## Methods: Methods included histology, immunohistochemistry and quantitative reverse transcriptase-polymerase chain reaction analysis. ## Results: Sun-exposed skin displayed the characteristic morphological and molecular features of dermal photoageing, compared with sun-protected skin, including dermal elastosis, diminished fibri
Who reads Decreased Expression of Keratinocyte β1 Integrins in Chronically Sun-exposed Skin in Vivo?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S. Bosset; M. Bonnet-Duquennoy; P. Barré; A. Chalon; K. Lazou; R. Kurfurst; F. Bonté; S. Schnébert; F. Disant; B. Le Varlet; J.F. Nicolas
- Publisher
- Oxford University Press (OUP)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)