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Early Cytokine Responses During Intestinal Parasitic Infections by ISHIKAWA; GOYAL; MAHIDA; LI; WAKELIN is a Immunology and Microbiology article available to read on EtoBox.

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Infections with gastro‐intestinal nematodes elicit immune and inflammatory responses mediated by cytokines released from T‐helper type‐2 (Th2) cells. __In vitro__ assays of cells from the mesenteric lymph nodes (MLN) of experimentally infected rodents confirm that, after about 1 week, the dominant cytokine responses to mitogens and antigens are those associated with this Th‐cell subset. Polarization of the Th response in this way implies an initial local cytokine enviroment that favours Th2 development. However, experimental infections with __Trichinella spiralis__ and __Nippostrongylus brasiliensis__ show that, within 2 days of worms reaching the intestine, MLN cells (MLNC) respond with a Th1 rather than a Th2 response [i.e. there is an increase in mRNA for the type 1 cytokine interferon‐γ (IFN‐γ), and mitogen‐stimulated MLNC release IFN‐γ rather than interleukin‐5 (IL‐5)]. Antigen stimulation at this time does not elicit IFN‐γ release and the MLNC cannot adoptively transfer immunity. Within a few days the MLNC phenotype changes. There is a Th2 response (IL‐5 release) to both mitogen and antigen stimulation and MLNC can adoptively transfer immunity. Early release of IFN‐γ is T‐cel

Who reads Early Cytokine Responses During Intestinal Parasitic Infections?

Author

ISHIKAWA; GOYAL; MAHIDA; LI; WAKELIN

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

1998

Language

EN

Field

Immunology and Microbiology (Life Sciences)