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Accuracy of Axillary Sentinel Lymph Node Biopsy Following Neoadjuvant (Induction) Chemotherapy for Carcinoma of the Breast by Gordon F. Schwartz; Andrew J. Meltzer is a Medicine article available to read on EtoBox.

What is Accuracy of Axillary Sentinel Lymph Node Biopsy Following Neoadjuvant (Induction) Chemotherapy for Carcinoma of the Breast about?

Sentinel lymph node biopsy (SLNB) is widely employed to detect axillary lymph node metastases in breast cancer patients with clinically negative (N0) axillae. One of the few reported contraindications to SLNB is prior treatment with systemic chemotherapy (neoadjuvant /induction chemotherapy). Previous investigators reported difficulty identifying the sentinel node and an unacceptable false-negative rate in this patient cohort. We present one experienced surgeon's experience with SLNB following induction chemotherapy ( n = 21). Following treatment with Adriamycin and Cytoxan (AC)-based cyclic chemotherapy, patients underwent SLNB, followed by levels I and II axillary lymph node dissection (ALND). At least one sentinel node was identified in all patients (100%). With respect to metastatic disease, the status of the sentinel node(s) accurately reflected the status of the axilla in 20 of 21 patients (95%). Eleven patients (52%) had axillary metastases identified by ALND. Of this group, SLNB failed to identify metastatic disease in one patient (9%). Previous treatment with induction chemotherapy should not be considered an absolute contraindication to SLNB. An experienced surgeon may ut

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Author

Gordon F. Schwartz; Andrew J. Meltzer

Publisher

Hindawi Limited

Published

2003

Language

EN

Field

Medicine (Health Sciences)