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Can I read Molecular Modeling Studies to Predict the Possible Binding Modes of Endomorphin Analogs in μ Opioid Receptor on EtoBox?
Molecular Modeling Studies to Predict the Possible Binding Modes of Endomorphin Analogs in μ Opioid Receptor by Xin Liu; Ming Kai; Lian Jin; Rui Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Molecular Modeling Studies to Predict the Possible Binding Modes of Endomorphin Analogs in μ Opioid Receptor about?
The molecular docking of a series of endomorphin analog with the mu opioid receptor was performed. The successive molecular dynamics of several proposed ligand-receptor complexes inserted into the phospholipid bilayer were carried out to optimize the complex and explore the conformational changes. Meaningful differences of their binding modes were detected and the involvement of some essential residues in ligand binding was also identified. Our proposed ligand-receptor model is in good agreement with previous site-directed mutagenesis experiments.
Who reads Molecular Modeling Studies to Predict the Possible Binding Modes of Endomorphin Analogs in μ Opioid Receptor?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xin Liu; Ming Kai; Lian Jin; Rui Wang
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)