Can I read Loss of Heterozygosity and Allelic Imbalance in Apocrine Metaplasia of the Breast: Microdissection Microsatellite Analysis on EtoBox?

Loss of Heterozygosity and Allelic Imbalance in Apocrine Metaplasia of the Breast: Microdissection Microsatellite Analysis by Abdel-Ghani A. Selim; Andy Ryan; Ghada El-Ayat; Clive A. Wells is a Medicine article available to read on EtoBox.

What is Loss of Heterozygosity and Allelic Imbalance in Apocrine Metaplasia of the Breast: Microdissection Microsatellite Analysis about?

## Abstract Loss of heterozygosity (LOH) and allelic imbalance (AI) at loci reported to show allele loss and/or imbalance in preinvasive and invasive breast cancer were examined in 41 cases of apocrine metaplasia (APM) of the breast using a microdissection technique, polymorphic microsatellite markers, and the polymerase chain reaction (PCR). Occasional examples of LOH and/or AI were identified in 2/28 (7.1%) informative cases at 1p (MYCL1), 2/14 (14.3%) at 11q (INT2), 1/15 (6.7%) at 13q (D13S267), 3/22 (13.6%) at 16q (D16S539), 2/23 (8.7%) at 17p (TP53), and 1/11 (9.1%) at 17p (D17S513) and 3/16 (18.8%) at 17q (D17S250). The finding of LOH/AI in cases of APM indicates that a subset of APM appears clonal, but the significance of allelic loss or imbalance in the pathogenesis of APM or its possible subsequent progression to carcinoma is not yet clear and requires further investigation. Clinical follow‐up of these particular cases of APM showing LOH/AI would be of further value. Copyright © 2002 John Wiley & Sons, Ltd.

Who reads Loss of Heterozygosity and Allelic Imbalance in Apocrine Metaplasia of the Breast: Microdissection Microsatellite Analysis?

Author

Abdel-Ghani A. Selim; Andy Ryan; Ghada El-Ayat; Clive A. Wells

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2002

Language

EN

Field

Medicine (Health Sciences)