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Nasal Absorption of Hydroxocobalamin in Healthy Elderly Adults by D. Z. B. Van Asselt; F. W. H. M. Merkus; F. G. M. Russel; W. H. L. Hoefnagels is a Medicine article available to read on EtoBox.

What is Nasal Absorption of Hydroxocobalamin in Healthy Elderly Adults about?

__Aims__ To investigate the nasal absorption of hydroxocobalamin in 10 healthy elderly adults. __Methods__ In a cross‐over study, blood samples were collected before administration of the drug and after 10, 20, 30, 40, 60, 120, 180 and 240 min. The plasma cobalamin concentration was determined by competitive radioisotope binding technique. __Results__ The maximal plasma cobalamin concentration (__C__~max~ ) after nasal administration of 750 μg hydroxocobalamin was 1900±900 pmol l^−1^ (mean±s.d.). The maximal plasma cobalamin concentration was reached in 35±13 min (__t__~max~ ). The __C__~max~ after nasal administration of 1500 μg hydroxocobalamin was 3500±2500 pmol l^−1^ with a __t__~max~ of 28±16 min. Both the AUC(0,240 min) and AUC(0,00) increased significantly with an increase of the dose from 750 μg to 1500 μg (__P__=0.037 and __P__=0.028, respectively). The nasal spray was well tolerated. No signs of irritation or local sensitivity were noted. __Conclusions__ The nasal absorption of hydroxocobalamin in healthy elderly adults is rapid, high and well tolerated.

Who reads Nasal Absorption of Hydroxocobalamin in Healthy Elderly Adults?

Author

D. Z. B. Van Asselt; F. W. H. M. Merkus; F. G. M. Russel; W. H. L. Hoefnagels

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1998

Language

EN

Field

Medicine (Health Sciences)