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The associations between concentrations of gestational bisphenol analogues and thyroid related hormones in cord blood: A prospective cohort study by Jianya Xi; Xiujuan Su; Ziliang Wang; Honglei Ji; Yao Chen; Xiaofang Liu; Maohua Miao; Hong Liang; Wei Yuan is a Environmental Science article available to read on EtoBox.
What is The associations between concentrations of gestational bisphenol analogues and thyroid related hormones in cord blood: A prospective cohort study about?
Animal studies indicated that Bisphenol analogues (BPs) exhibited potential thyroid toxicity. However, little is known of the associations between maternal BPs exposure and offspring’s thyroid related hormones in humans. On the basis of Shanghai-Minhang Birth Cohort study, we analyzed BPs in maternal urine collected at the third trimester of pregnancy. Thyroid related hormones (THs), including total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were measured in cord blood samples. We performed multiple linear regression and Bayesian kernel machine regression (BKMR) models to explore the single and joint effects of gestational BPs exposure on thyroid related hormones in cord blood among 258 mother-child pairs. Statistically significant inverse associations of categorized BPA with FT3 and TT4 concentrations were observed. We also found a significant association between the mixture of BPs in maternal urine and increased concentration of TT3 in cord blood and a marginally significant association between BPs mixture and increased FT3 concentrations. Further associations of BPA with lower TT4/FT4 an
Who reads The associations between concentrations of gestational bisphenol analogues and thyroid related hormones in cord blood: A prospective cohort study?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Jianya Xi; Xiujuan Su; Ziliang Wang; Honglei Ji; Yao Chen; Xiaofang Liu; Maohua Miao; Hong Liang; Wei Yuan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)