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Single-Inhaler Triple Therapy in Patients with Advanced COPD: Bayesian Modeling of the Healthcare Resource Utilization Data and Associated Costs from the IMPACT Trial by Andrea Gabrio; Necdet B Gunsoy; Gianluca Baio; Alan Martin; Victoria F Paly; Nancy Risebrough; David M G Halpin; Dave Singh; Robert A Wise; MeiLan K Han; Fernando J Martinez; Gerard J Criner; Neil Martin; David A Lipson; Afisi S Ismaila is a Medicine article available to read on EtoBox.

What is Single-Inhaler Triple Therapy in Patients with Advanced COPD: Bayesian Modeling of the Healthcare Resource Utilization Data and Associated Costs from the IMPACT Trial about?

## Abstract ## Objectives In the IMPACT trial (NCT02164513), triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) showed clinical benefit compared with dual therapy with either FF/VI or UMEC/VI in the treatment of chronic obstructive pulmonary disease (COPD). We used data from IMPACT to determine whether this translated into differences in COPD-related healthcare resource utilization (HRU) costs in a United Kingdom (UK) setting. ## Methods In a within-trial analysis, individual patient data from the IMPACT intention-to-treat (ITT) population were analyzed to estimate rates of COPD-related HRU with FF/UMEC/VI, FF/VI, or UMEC/VI. A Bayesian approach was applied to address issues typically encountered with this kind of data, namely data missing due to early study withdrawal, subjects with zero reported HRU, and skewness. Rates of HRU were estimated under alternate assumptions of data being missing at random (MAR) or missing not at random (MNAR). UK-specific unit costs were then applied to estimated HRU rates to calculate treatment-specific costs. ## Results Under each MNAR scenario, per patient per year (PPPY) rates of COPD-related HRU were lowest amongst those

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Author

Andrea Gabrio; Necdet B Gunsoy; Gianluca Baio; Alan Martin; Victoria F Paly; Nancy Risebrough; David M G Halpin; Dave Singh; Robert A Wise; MeiLan K Han; Fernando J Martinez; Gerard J Criner; Neil Martin; David A Lipson; Afisi S Ismaila

Published

2022

Language

EN

Field

Medicine (Health Sciences)