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Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes: Asthma Candidate Gene SNP Analysis by Thomas Immervoll; Sabine Loesgen; Gabriele Dütsch; Henning Gohlke; Nicole Herbon; Sabine Klugbauer; Astrid Dempfle; Heike Bickeböller; Johannes Becker-Follmann; Franz Rüschendorf; Kathrin Saar; Andre Reis; H.-Erich Wichmann; Matthias Wjst is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes: Asthma Candidate Gene SNP Analysis about?

Several genome-wide screens for asthma and related phenotypes have been published to date but data on fine-mapping are scarce. For higher resolution we performed a fine-mapping study with 2 cM average spacing in often discussed asthma candidate regions (2p, 5q, 6p, 7p, 9q, 11p, and 12q) to narrow down the regions of interest. All participants of a Caucasian family study (97 families with at least two affected sib pairs) were genotyped for 49 supplementary polymorphic dinucleotide markers. Our results indicate increased evidence for linkage on chromosome 6p, 9q, and 12q. These candidate regions were further analyzed with SNP polymorphisms in the endothelin 1 (EDN1), lymphotoxin alpha (LTA), and neuronal nitric oxide synthase (NOS1) genes. In addition, IL4 -590C>T and IL10 -592C>A, localized on chromosomes 5q and 1q, respectively, have been analyzed for SNP association. Of the six SNPs tested, four revealed weak association with the examined phenotypes. These are the IL10 -592C>A SNP in the interleukin 10 gene (p=0.036 for eosinophil cell counts), the 4124T>C SNP in EDN1 (p=0.044 for asthma), the 3391C>T SNP in NOS1 with eosinophil cell counts (p=0.0086), and the 5266C>T polymorphism

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Author

Thomas Immervoll; Sabine Loesgen; Gabriele Dütsch; Henning Gohlke; Nicole Herbon; Sabine Klugbauer; Astrid Dempfle; Heike Bickeböller; Johannes Becker-Follmann; Franz Rüschendorf; Kathrin Saar; Andre Reis; H.-Erich Wichmann; Matthias Wjst

Publisher

Hindawi Limited

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)