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Pesticide Exposure and Risk of Aggressive Prostate Cancer Among Private Pesticide Applicators by Pardo, Larissa A.; Beane Freeman, Laura E.; Lerro, Catherine C.; Andreotti, Gabriella; Hofmann, Jonathan N.; Parks, Christine G.; Sandler, Dale P.; Lubin, Jay H.; Blair, Aaron; Koutros, Stella is a Environmental Science article available to read on EtoBox.
What is Pesticide Exposure and Risk of Aggressive Prostate Cancer Among Private Pesticide Applicators about?
## Background Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men in developed countries; however, little is known about modifiable risk factors. Some studies have implicated organochlorine and organophosphate insecticides as risk factors (particularly the organodithioate class) and risk of clinically significant PCa subtypes. However, few studies have evaluated other pesticides. We used data from the Agricultural Health Study, a large prospective cohort of pesticide applicators in North Carolina and Iowa, to extend our previous work and evaluate 39 additional pesticides and aggressive PCa. ## Methods We used Cox proportional hazards models, with age as the time scale, to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between ever use of individual pesticides and 883 cases of aggressive PCa (distant stage, poorly differentiated grade, Gleason score ≥ 7, or fatal prostate cancer) diagnosed between 1993 and 2015. All models adjusted for birth year, state, family history of PCa, race, and smoking status. We conducted exposure-response analyses for pesticides with reported lifetime years of use. ## Results There was an inc
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- Author
- Pardo, Larissa A.; Beane Freeman, Laura E.; Lerro, Catherine C.; Andreotti, Gabriella; Hofmann, Jonathan N.; Parks, Christine G.; Sandler, Dale P.; Lubin, Jay H.; Blair, Aaron; Koutros, Stella
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, c2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1476-069X)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)