Can I read TNF-α â 308âG/A and IFN-Î3 + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis on EtoBox?

TNF-α â 308âG/A and IFN-Î3 + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis by Ahmed, Ahmed A.; Rasheed, Zafar; Salem, Tarek; Al-Dhubaibi, Mohammed S.; Al Robaee, Ahmad A.; Alzolibani, Abdullateef A. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is TNF-α â 308âG/A and IFN-Î3 + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis about?

## Background Cutaneous leishmaniasis (CL) is well linked with immunogenetic factors. This study was undertaken to test the association of TNF-α − 308 and IFN-γ + 874 gene polymorphisms with the susceptibility of __Leishmania (L) species__ among CL patients in central region of Saudi Arabia. ## Methods This is a case-control study involved 169 Saudi subjects with different __L. species__ and 199 healthy controls from central region of Saudi Arabia. All subjects were characterized by TNF-α − 308 G/A and IFN-γ + 874 A/T gene polymorphisms using PCR. ## Results Evaluation of genotyping and allelic frequency of TNF-α − 308 G/A in different __L. species__ showed no significant association compared to controls (__p__ > 0.05). Except, in cases of __L. tropica__ that showed significantly higher TNF-α − 308 A versus G allele frequency (__p__ = 0.0004). Evaluation of genotyping of IFN-γ + 874 (TT versus AA+AT recessive) and allelic frequency of IFN-γ + 874 (T versus A) showed significant higher in __L. major__ and also in total CL cases as compared to healthy controls (__p__ < 0.05). Furthermore, a strong association was observed between the susceptibility of __L. major__, __L. tropica or__

Who reads TNF-α â 308âG/A and IFN-Î3 + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis?

Author

Ahmed, Ahmed A.; Rasheed, Zafar; Salem, Tarek; Al-Dhubaibi, Mohammed S.; Al Robaee, Ahmad A.; Alzolibani, Abdullateef A.

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2350)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)