Opening book details…
Can I read Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells on EtoBox?
Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells by Victoria Jiménez-Castillo; Daniela Illescas-Barbosa; Edgar Zenteno; Beatriz Xóchitl Ávila-Curiel; Maria Cristina Castañeda-Patlán; Martha Robles-Flores; Daniel Montante-Montes De Oca; Eduardo Pérez-Campos; Anayetzin Torres-Rivera; Abdelouhab Bouaboud; Patrick Pagesy; Carlos Josué Solórzano-Mata; Tarik Issad is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells about?
## Abstract O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification on serine and threonine residues of cytosolic, nuclear and mitochondrial proteins. O-GlcNAcylation level is regulated by OGT (O-GlcNAc transferase), which adds GlcNAc on proteins, and OGA (O-GlcNAcase), which removes it. Abnormal level of protein O-GlcNAcylation has been observed in numerous cancer cell types, including cervical cancer cells. In the present study, we have evaluated the effect of increasing protein O-GlcNAcylation on cervical cancer-derived CaSki cells. We observed that pharmacological enhancement of protein O-GlcNAcylation by Thiamet G (an inhibitor of OGA) and glucosamine (which provides UDP-GlcNAc substrate to OGT) increases CaSki cells proliferation, migration and survival. Moreover, we showed that increased O-GlcNAcylation promotes IGF-1 receptor (IGF1R) autophosphorylation, possibly through inhibition of protein tyrosine-phosphatase 1B activity. This was associated with increased IGF-1-induced phosphatidyl-Inositol 3-phosphate production at the plasma membrane and increased Akt activation in CaSki cells. Finally, we showed that protein O-GlcNAcyla
Who reads Increased O-GlcNAcylation promotes IGF-1 receptor/PhosphatidyI Inositol-3 kinase/Akt pathway in cervical cancer cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Victoria Jiménez-Castillo; Daniela Illescas-Barbosa; Edgar Zenteno; Beatriz Xóchitl Ávila-Curiel; Maria Cristina Castañeda-Patlán; Martha Robles-Flores; Daniel Montante-Montes De Oca; Eduardo Pérez-Campos; Anayetzin Torres-Rivera; Abdelouhab Bouaboud; Patrick Pagesy; Carlos Josué Solórzano-Mata; Tarik Issad
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)