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Dysregulated Oxidative Stress and Lactate Levels in Treatment-resistant Schizophrenia by Yehong Fang & Tingkai Zhang & Kai Xu & Liangliang Wang & Jingqi He & Yanhui Liao & Ning Yuan & Jinsong Tang is a nonfiction available to read on EtoBox.

What is Dysregulated Oxidative Stress and Lactate Levels in Treatment-resistant Schizophrenia about?

Brain Behavior and Immunity, Journal Pre-proof, 106111. doi:10.1016/j.bbi.2025.106111Abstract37 Schizophrenia is a severe and clinically heterogeneous mental disorder, with 38 approximately 30% of patients developing treatment resistance to standard 39 antipsychotics. To elucidate the pathophysiological mechanisms underlying 40 treatment-resistant schizophrenia (TRS), we performed a comparative 41 proteomic analysis of plasma-derived extracellular vesicles (EVs) from TRS 42 patients, non-TRS (NTRS) patients, and healthy controls (n=29, 29, and 31, 43 respectively). EVs from TRS and NTRS patients induced schizophrenia-like 44 behavioral deficits in mice, such as impaired prepulse inhibition and reduced 45 social interaction, while healthy control-derived EVs ameliorated these deficits 46 in an MK-801-induced model. In vitro, TRS-EVs triggered concurrent 47 proliferation and apoptosis in astrocytes and induced dendritic abnormalities in 48 neurons more prominently than NTRS-EVs. Proteomic profiling revealed 49 significant dysregulation in TRS-derived EVs, featuring decreased oxygen 50 transport and antioxidant proteins (e.g., HBG1, HBB, PRDX2) and elevated 51 glycolytic enzymes (e.g.

Who reads Dysregulated Oxidative Stress and Lactate Levels in Treatment-resistant Schizophrenia?

Author

Yehong Fang & Tingkai Zhang & Kai Xu & Liangliang Wang & Jingqi He & Yanhui Liao & Ning Yuan & Jinsong Tang

Publisher

The Author(s)

Published

2025

Language

EN

Category

nonfiction

Subjects

Science, Human Biology, Stem