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Can I read Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation on EtoBox?
Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation by Hsia, Chih-Hsuan; Jayakumar, Thanasekaran; Sheu, Joen-Rong; Hsia, Chih-Wei; Huang, Wei-Chieh; Velusamy, Marappan; Lien, Li-Ming is a Medicine article available to read on EtoBox.
What is Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation about?
Activated microglia are crucial in the regulation of neuronal homeostasis and neuroinflammation. They also contribute to neuropathological processes after ischemic stroke. Thus, finding new approaches for reducing neuroinflammation has gained considerable attention. The metal ruthenium has gained notable attention because of its ability to form new complexes that can be used in disease treatment. [Ru(η6-cymene)2-(1H-benzoimidazol-2-yl)-quinoline Cl]BF4 (TQ-6), a potent ruthenium (II)-derived compound, was used in this study to investigate its neuroprotective action against microglia activation, middle cerebral artery occlusion (MCAO)-induced embolic stroke, and platelet activation, respectively. TQ-6 (2 μM) potently diminished inflammatory mediators (nitric oxide/inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2)) expression, nuclear factor kappa B (NF-κB) p65 phosphorylation, nuclear translocation, and hydroxyl radical (OH^•^) formation in LPS-stimulated microglia. Conversely, TQ-6 increased the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). Moreover, it significantly reduced brain infarct volume and edema in MCAO mic
Who reads Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation?
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- Author
- Hsia, Chih-Hsuan; Jayakumar, Thanasekaran; Sheu, Joen-Rong; Hsia, Chih-Wei; Huang, Wei-Chieh; Velusamy, Marappan; Lien, Li-Ming
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI) (ISSN 2077-0383)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)