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Erythema Multiforme Is Rarely Drug-induced is a Medicine article available to read on EtoBox.

Erythema multiforme is rarely drug-induced Drug-induced erythema multiforme (EM) appears to be rare, according to findings of a French study published in Therapies.Investigators reviewed all cases of clinically typical EM and/or EM validated by a dermatologist which were reported in the French pharmacovigilance database during 2008-2009 and 2018-2019. EM was considered to be drug-induced if the time to onset was 5-28 days and there was no alternative cause.Of the 140 reported cases of EM, 48% presented as an alternative diagnosis. Of the 73 cases considered to be EM, 49% had a probable non-drug cause and 38% had a reported suspect drug but the time to onset of EM was ≤4 days and/ or ≥29 days. Therefore, only nine (6%) cases were considered to be possible drug-induced EM.Etiology of EM was more frequently investigated in cases reported in 2018-2019 than in 2008-2009 (53% vs 29%; p<0.04), and 5-28 days to onset was more frequently reported in cases reported in 2018-2019 (59% vs 40%; p=0.04).Drugs associated with a time to onset of 5-28 days included allopurinol, immunomodulators (25%), anti-infectives (23%) and antiepileptics/psychotropics (18%)."Our study suggests that EM is rarely

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)