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Can I read A three-dimensional integration strategy for Q-markers identification: Taken Euphorbia Pekinensis Radix as an example on EtoBox?
A three-dimensional integration strategy for Q-markers identification: Taken Euphorbia Pekinensis Radix as an example by Xiao-Tao Zeng; Yan-Yan Chen; Shi-Jun Yue; Ding-Qiao Xu; Rui-Jia Fu; Jie-Yang; Yu-Ping Tang is a Chemistry article available to read on EtoBox.
What is A three-dimensional integration strategy for Q-markers identification: Taken Euphorbia Pekinensis Radix as an example about?
Euphorbia Pekinensis Radix (EPR) is an important antitumor medicinal resource. However, quality control of EPR has not been well established due to the lack of quality markers (Q-markers) research. In this study, a three-dimensional integration strategy was developed to systematically characterize Q-markers and this method was successfully applied to identify Q-markers of EPR. Firstly, three core quality attributes-effectiveness, testability and specificity-were considered as three dimensions, and the weights of each dimension were calculated by analytical hierarch process. Then, the values of each dimension were evaluated by multi-indicators. For EPR with antitumor activity, cytotoxic assay and network pharmacology, UPLC analysis and literature search, compound belonging search were employed to calculate the values of effectiveness, testability and specificity, respectively. Finally, the weights and values were multiplied as the scores of each component on that dimension, and the total scores of the three dimensions were further integrated based on the radar plot and expressed as regression area, by which Q-markers were quantified and visualized. Five components were identified as
Who reads A three-dimensional integration strategy for Q-markers identification: Taken Euphorbia Pekinensis Radix as an example?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Xiao-Tao Zeng; Yan-Yan Chen; Shi-Jun Yue; Ding-Qiao Xu; Rui-Jia Fu; Jie-Yang; Yu-Ping Tang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)