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Tissue Response and Biomaterial Integration: the Efficacy of in Vitro Methods by C.J Kirkpatrick; V Krump-Konvalinkova; R.E Unger; F Bittinger; M Otto; K Peters is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Tissue Response and Biomaterial Integration: the Efficacy of in Vitro Methods about?

Implantation involves tissue trauma, which evokes an inflammatory response, coupled to a wound healing reaction, involving angiogenesis, fibroblast activation and matrix remodelling. Until now the type and extent of such reactions to give optimal integration of various biomaterials are practically unknown. Three principal fields of research can yield useful data to understand these phenomena better: studies on explanted biomaterials, animal models and relevant in vitro techniques. This paper will present examples of the latter field and the application of endothelial cell (EC) culture systems to study the effects of important tissue (e.g. pro-inflammatory cytokines, chemokines) and material (e.g. metal ions, particulate debris) factors on the regulation of the inflammatory and angiogenic response. A central feature is the use of microvascular endothelial cells (MEC), which can be used in both 2-and 3-dimensional (3-D) assays. We have also used genetic manipulation to develop a permanent MEC line from the human lung (HPMEC-ST1), which is being tested for its suitability to study cell-biomaterial interactions. In addition, suitable in vitro techniques are being developed in order to

Who reads Tissue Response and Biomaterial Integration: the Efficacy of in Vitro Methods?

Author

C.J Kirkpatrick; V Krump-Konvalinkova; R.E Unger; F Bittinger; M Otto; K Peters

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1389-0344)

Published

2002

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)