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Stroke-Induced Immunodepression: Experimental Evidence and Clinical Relevance by Ulrich Dirnagl; Juliane Klehmet; Johann S. Braun; Hendrik Harms; Christian Meisel; Tjalf Ziemssen; Konstantin Prass; Andreas Meisel is a Medicine article available to read on EtoBox.

What is Stroke-Induced Immunodepression: Experimental Evidence and Clinical Relevance about?

Stroke affects the normally well-balanced interplay of the 2 supersystems: the nervous and the immune system. Recent research elucidated some of the involved signals and mechanisms and, importantly, was able to demonstrate that brain-immune interactions are highly relevant for functional outcome after stroke. Immunodepression after stroke increases the susceptibility to infection, the most relevant complication in stroke patients. However, immunodepression after stroke may also have beneficial effects, for example, by suppressing autoaggressive responses during lesion-induced exposure of central nervous system-specific antigens to the immune system. Thus, before immunomodulatory therapy can be applied to stroke patients, we need to understand better the interaction of brain and immune system after focal cerebral ischemia. Until then, anticipating an important consequence of stroke-induced immunodepression, bacterial infection, preventive antibiotic strategies have been proposed. In mouse experiments, preventive antibiotic treatment dramatically improves mortality and outcome. Results of clinical studies on this issue are contradictory at present, and larger trials are needed to set

Who reads Stroke-Induced Immunodepression: Experimental Evidence and Clinical Relevance?

Author

Ulrich Dirnagl; Juliane Klehmet; Johann S. Braun; Hendrik Harms; Christian Meisel; Tjalf Ziemssen; Konstantin Prass; Andreas Meisel

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2007

Language

EN

Field

Medicine (Health Sciences)