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Reduced Risk of Apoptosis: Mechanisms of Stress Responses by Irina Milisav; Borut Poljšak; Samo Ribarič is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Reduced Risk of Apoptosis: Mechanisms of Stress Responses about?

Apoptosis signaling pathways are integrated into a wider network of interconnected apoptotic and anti-apoptotic pathways that regulate a broad range of cell responses from cell death to growth, development and stress responses. An important trigger for anti- or pro-apoptotic cell responses are different forms of stress including hypoxia, energy deprivation, DNA damage or inflammation. Stress duration and intensity determine whether the cell's response will be improved cell survival, due to stress adaptation, or cell death by apoptosis, necrosis or autophagy. Although the interplay between enhanced stress tolerance and modulation of apoptosis triggering is not yet fully understood, there is a substantial body of experimental evidence demonstrating that apoptosis and anti-apoptosis signaling pathways can be manipulated to trigger or delay apoptosis in vitro or in vivo. Anti-apoptotic strategies cover a broad range of approaches. These interventions include mediators that prevent apoptosis (trophic factors and cytokines), apoptosis inhibition (caspase inhibition, stimulation of anti-apoptotic or inhibition of pro-apoptotic proteins and elimination of apoptotic stimulus), adaptive stre

Who reads Reduced Risk of Apoptosis: Mechanisms of Stress Responses?

Author

Irina Milisav; Borut Poljšak; Samo Ribarič

Publisher

Springer Science and Business Media LLC

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)