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Regulation of gene expression in melanoma: New approaches for treatment by Michael C. Leslie; Menashe Bar-Eli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The molecular changes associated with the transition of melanoma cells from radial growth phase (RGP) to vertical growth phase (VGP, metastatic phenotype) are not yet well defined. We have demonstrated that the progression of human melanoma is associated with loss of expression of the transcription factor AP‐2. In metastatic melanoma cells, this loss resulted in overexpression of MCAM/MUC18, MMP‐2, the thrombin receptor (PAR‐1), and lack of c‐KIT expression. The transition from RGP to VGP is also associated with overexpression of the angiogenic factor IL‐8. Additionally, the transition of melanoma cells from RGP to VGP is associated with overexpression of the transcription factors CREB and ATF‐1, both of which may act as survival factors for human melanoma cells. Inactivation of CREB/ATF‐1 activities in metastatic melanoma cells by dominant‐negative CREB or by anti‐ATF‐1 single chain antibody fragment (ScFv), resulted in deregulation of MMP‐2 and MCAM/MUC18, increased the sensitivity of melanoma cells to apoptosis, and inhibition of their tumorigenicity and metastatic potential in vivo. In this prospect article, we summarize our data on the role of AP‐2 and CREB/ATF‐1 i

Who reads Regulation of gene expression in melanoma: New approaches for treatment?

Author

Michael C. Leslie; Menashe Bar-Eli

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)