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Chemopreventive effect of difluoromethylornithine (DMFO) on mouse skin squamous cell carcinomas induced by Benzo(a)pyrene by Mitsunaga, Shin-ichiro; Clapper, Margie; Litwin, S.; Watts, P.; Bauer, B.; Klein-Szanto, A.J.P. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The effect of the chemopreventive agent D,L-␣-difluoromethylornithine (DFMO) on the incidence of skin squamous cell carcinoma was studied in SENCAR mice treated weekly with topical applications of benzo(a)pyrene (B(a)P) (0.15 mmol, 2ϫ/week) on the dorsal skin. Animals were randomized to receive either chow or chow supplemented with DFMO (1 g/1 kg) and studied at 10, 15, 20, 25, and 30 weeks of B(a)P treatment. Morphometric analyses at each timepoint evaluated the epidermal thickness (ET) and the number of epidermal nucleated layers (NL). The ET increased from 12-17 μm as early as 10 weeks after B(a)P treatment, reaching 22 μm at 20 weeks, and 27 μm at 25 weeks (130% increase). The NL also increased markedly. A relatively modest increase in ET was observed in animals treated with B(a)P and DFMO (16% at 15 weeks, 53% at 20 weeks, and 85% at 25 weeks) as compared to controls. The relative increase in NL showed a similar pattern. Although extensive epidermal hyperplasia was seen early, clear-cut focal premalignant lesions were not identifiable before week 20 of B(a)P treatment. At 20 weeks, the most frequently noted focal premalignant lesions in carcinogen-treated animals (without DFMO

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Author

Mitsunaga, Shin-ichiro; Clapper, Margie; Litwin, S.; Watts, P.; Bauer, B.; Klein-Szanto, A.J.P.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1997

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)