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Contribution of Na^+^/Ca^2+^ exchanger to the regulation of myogenic tone in isolated rat small arteries by S. Horiguchi; J. Watanabe; H. Kato; S. Baba; T. Shinozaki; M. Miura; M. Fukuchi; Y. Kagaya; K. Shirato is a Medicine article available to read on EtoBox.
What is Contribution of Na^+^/Ca^2+^ exchanger to the regulation of myogenic tone in isolated rat small arteries about?
The contribution of the Na^+^/Ca^2+^ exchanger to the myogenic vascular tone was examined in rat isolated skeletal muscle small arteries (A~SK~) with pronounced myogenic tone and mesenteric small arteries (A~MS~) with little myogenic tone. Myogenic tone was assessed by the vascular inner diameter at transmural pressures of 40 and 100 mmHg. To depress the Na^+^/Ca^2+^ exchanger, the extracellular Na^+^ concentration ([Na^+^]o) was lowered from 143 to 1.2 mM by substituting choline‐Cl for NaCl. The A~SK~ developed significant myogenic tone and constricted further in low [Na^+^]o. Nifedipine (1 __μ__M) reduced both myogenic tone and low [Na^+^]o‐induced contraction. Because the membrane potential of A~SK~ was not changed by low [Na^+^]o (–35 ± 2 mV at 143 mM [Na^+^]o, −37 ± 3 mV at 1.2 mM [Na^+^]o), depolarization‐induced Ca^2+^ influx was not a cause of the low [Na^+^]o‐induced contraction. The A~MS~ did not develop significant myogenic tone. Although low [Na^+^]o also constricted A~MS~, the magnitude of constriction was significantly weaker than that in A~SK~ (17 ± 4 vs. 47 ± 6%, __P__< 0.01, at 58 mM Na^+^). With Bay K 8644, A~MS~ developed myogenic tone, and low [Na^+^]o‐induced c
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- Author
- S. Horiguchi; J. Watanabe; H. Kato; S. Baba; T. Shinozaki; M. Miura; M. Fukuchi; Y. Kagaya; K. Shirato
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-6772)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Life Sciences)