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Hirsutism: with 32 Figures and 10 Tables by P. Mauvais-Jarvis; F. Kuttenn; I. Mowszowicz is a book available to read on EtoBox.

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In the past 10 years hirsutism has been the object of a considerable number of fundamental studies. It provides endocrinologists with an experimental model for the investigation of androgen secretion, metabolism and mechanism of action. Plasma androgen assay, free testosterone measurement, hepatic and extrahepatic androgen metabolic clearance and androgen metabolism in the skin are the different steps which were studied by many groups and represent valuable parameters of the mechanisms of hirsutism. Determination of the origin of androgen oversecretion has become easier by technical progress in differential effiuent venous catheterism, which makes it possible to compare androgens in adrenal or ovarian effiuent veins to their peripheral levels, and to determine the ovarian or adrenal source of the androgen oversecretion as well as the side responsible, essential in the case of tumors. The study of androgen metabolism and the discovery of androgen receptors in the skin confIrm the latter as an actual target cell for androgens. This target cell uses the circulating active androgen, i. e., testosterone and can also metabolize local inactive androgens into active ones. This is the case

Author

P. Mauvais-Jarvis; F. Kuttenn; I. Mowszowicz

Publisher

Springer Spektrum. in Springer-Verlag GmbH

Published

2012

Language

EN

ISBN

9780387105093

Subjects

Medical, Medicine