Can I read Impaired Immune Health in Survivors of Diffuse Large B-Cell Lymphoma on EtoBox?

Impaired Immune Health in Survivors of Diffuse Large B-Cell Lymphoma by Tanaya Shree; Qian Li; Sally L. Glaser; Ann Brunson; Holden T. Maecker; Robert W. Haile; Ronald Levy; Theresa H. M. Keegan is a Medicine article available to read on EtoBox.

What is Impaired Immune Health in Survivors of Diffuse Large B-Cell Lymphoma about?

## PURPOSE Therapeutic advances for diffuse large B-cell lymphoma (DLBCL) have led to an increasing number of survivors. Both DLBCL and its treatments perturb the immune system, yet little is known about immune health during extended survivorship. ## METHODS In this retrospective cohort study, we compared 21,690 survivors of DLBCL from the California Cancer Registry (CCR) to survivors of breast, prostate, head and neck, and melanoma cancers. We linked their CCR records to a statewide database documenting hospital, emergency room, and ambulatory surgery visits and investigated the incidence of autoimmune conditions, immune deficiencies, and infections 1-10 years after cancer diagnosis. ## RESULTS We found elevated incidence rate ratios (IRRs) for many immune-related conditions in survivors of DLBCL compared with other cancer survivors, including significantly and consistently elevated IRRs for viral and fungal pneumonias (up to 10.8-fold), meningitis (up to 5.3-fold), as well as humoral deficiency (up to 17.6-fold) and autoimmune cytopenias (up to 12-fold). IRRs for most conditions remained high even in the late survivorship period (5-10 years after cancer diagnosis). The elevated r

Who reads Impaired Immune Health in Survivors of Diffuse Large B-Cell Lymphoma?

Author

Tanaya Shree; Qian Li; Sally L. Glaser; Ann Brunson; Holden T. Maecker; Robert W. Haile; Ronald Levy; Theresa H. M. Keegan

Publisher

American Society of Clinical Oncology; American Society of Clinical Oncology (ASCO) (ISSN 0732-183X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)