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Can I read (±)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines on EtoBox?
(±)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines by Chaquip D. Netto; Eduardo S.J. Santos; Carolina Pereira Castro; Alcides J.M. da Silva; Vivian M. Rumjanek; Paulo R.R. Costa is a Chemistry article available to read on EtoBox.
What is (±)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines about?
Naturally occurring pterocarpans 1a,b, pterocarpan 1c, isoflavane 2 and ortho-quinone 3 were synthesized in the racemic form and their cytotoxic effect was evaluated on the human leukemia cell lines K562 (resistant to oxidative stress), Lucena-1 (MDR phenotype) and HL-60. Ortho-quinone 3 (IC 50 1⁄4 1.5 mM, 1.8 mM and 0.2 mM, respectively) and catechol pterocarpan 1a (IC 50 1⁄4 3.0 mM, 3.7 mM and 2.1 mM, respectively) were the most active compounds on these cells and were also evaluated on other human leukemia cell lines (Jurkat and Daudi). Orthoquinone 3 was 2 to 10 times more potent than pterocarpan 1a, depending on the cell line considered, however, showed a greater toxicity for lymphocytes activated by PHA.
Who reads (±)-3,4-Dihydroxy-8,9-methylenedioxypterocarpan and derivatives: Cytotoxic effect on human leukemia cell lines?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Chaquip D. Netto; Eduardo S.J. Santos; Carolina Pereira Castro; Alcides J.M. da Silva; Vivian M. Rumjanek; Paulo R.R. Costa
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)