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Proteomic and Metabolomic Characterization of Cardiac Tissue in Acute Myocardial Ischemia Injury Rats by Bai, Hua; Sun, Ke; Wu, Jia-Hong; Zhong, Ze-Hao; Xu, Sen-Lei; Zhang, Hong-Ru; Gu, Yi-Huang; Lu, Sheng-Feng; Wang, Meijing is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Proteomic and Metabolomic Characterization of Cardiac Tissue in Acute Myocardial Ischemia Injury Rats about?

The pathological process and mechanism of myocardial ischemia (MI) is very complicated, and remains unclear. An integrated proteomic-metabolomics analysis was applied to comprehensively understand the pathological changes and mechanism of MI. Male Sprague-Dawley rats were randomly divided into a mock surgery (MS) group and an MI group. The MI model was made by ligating the left anterior descending coronary artery, twenty-four hours after which, echocardiography was employed to assess left ventricular (LV) function variables. Blood samples and left ventricular tissues were collected for ELISA, metabolomics and proteomics analysis. The results showed that LV function, including ejection fraction (EF) and fractional shortening (FS), was significantly reduced and the level of cTnT in the serum increased after MI. iTRAQ proteomics showed that a total of 169 proteins were altered including 52 and 117 proteins with increased and decreased expression, respectively, which were mainly involved in the following activities: complement and coagulation cascades, tight junction, regulation of actin cytoskeleton, MAPK signaling pathway, endocytosis, NOD-like receptor signaling pathway, as well as

Who reads Proteomic and Metabolomic Characterization of Cardiac Tissue in Acute Myocardial Ischemia Injury Rats?

Author

Bai, Hua; Sun, Ke; Wu, Jia-Hong; Zhong, Ze-Hao; Xu, Sen-Lei; Zhang, Hong-Ru; Gu, Yi-Huang; Lu, Sheng-Feng; Wang, Meijing

Publisher

Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)