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The N‐glycan profile in cortex and hippocampus is altered in Alzheimer disease by Stefan Gaunitz; Lars O. Tjernberg; Sophia Schedin‐Weiss is a Neuroscience article available to read on EtoBox.

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## Abstract Protein glycosylation is crucial for the central nervous system and brain functions, including processes that are defective in Alzheimer disease (AD) such as neurogenesis, synaptic function, and memory formation. Still, the roles of glycans in the development of AD are relatively unexplored. Glycomics studies of cerebrospinal fluid (CSF) have previously shown altered glycosylation pattern in patients with different stages of cognitive impairment, including AD, compared to healthy controls. As a consequence, we hypothesized that the glycan profile is altered in the brain of patients with AD and analyzed the asparagine‐linked (N‐linked) glycan profile in hippocampus and cortex in AD and control brain. Glycans were enzymatically liberated from brain glycoproteins and analyzed by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Eleven glycans showed significantly different levels in hippocampus compared to cortex in both control and AD brain. Two glycans in cortex and four in hippocampus showed different levels in AD compared to control brain. All glycans that differed between controls and AD brain had similar structures with one sialic acid, at least one fucose a

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Author

Stefan Gaunitz; Lars O. Tjernberg; Sophia Schedin‐Weiss

Publisher

Wiley

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)