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Can I read 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease on EtoBox?
11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease by K. Serdons; T. Verduyckt; D. Vanderghinste; P. Borghgraef; J. Cleynhens; F. Van Leuven; H. Kung; G. Bormans; A. Verbruggen is a Chemistry article available to read on EtoBox.
What is 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease about?
Pittsburgh Compound-B (PIB) is currently being evaluated clinically for in vivo visualization of amyloid plaques in patients with Alzheimer's disease (AD). We have synthesized three structural isomers of 6hydroxy-2-(4 0 -aminophenyl)-1,3-benzothiazole, performed radiolabelling with carbon-11 and investigated their in vivo and in vitro properties. Specific binding to amyloid plaques was demonstrated in vitro using post-mortem brain homogenates of AD patients, transgenic AD mice brain sections and postmortem human AD brain sections. In normal mice, initial brain uptake (at 2 min p.i.) was high and was followed by a fast wash-out. The three structural analogues have a high potential as tracer agents for in vivo visualization of amyloid plaques in AD patients.
Who reads 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- K. Serdons; T. Verduyckt; D. Vanderghinste; P. Borghgraef; J. Cleynhens; F. Van Leuven; H. Kung; G. Bormans; A. Verbruggen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2009
- Language
- EN
- Field
- Chemistry (Physical Sciences)