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The Use Of 18-fluorodeoxyglucose Positron Emission And Computed Tomography In The Evaluation Of Marfan Syndrome Patients by Styliani V. Brili; Viktor Gkotzamanis; Pavlos Kafouris; Vasiliki-Chara Mystakidi; Athanasios Sakalidis; Alexis S. Antonopoulos; Evangelos Oikonomou; Constantinos Anagnostopoulos; Konstantinos Tsioufis is a Medicine article available to read on EtoBox.
What is The Use Of 18-fluorodeoxyglucose Positron Emission And Computed Tomography In The Evaluation Of Marfan Syndrome Patients about?
Background: In previous studies the role of inflammation in Marfan Syndrome (MS) has been well recognized. These studies have elucidated the role of serum Interleukin 6 (IL-6), Transforming Growth Factor-b (TGF-b) and Macrophage Colony Stimulating Factor (MCSF) as markers of disease severity and progression. On the other hand, surgical repair for aortic aneurysms is recommended when the aortic diameter reaches the indication threshold, however aortic dissection may occur even before this is reached. 18-fluorodeoxyglucose (18 F-FDG) positron emission tomography / computed tomography (PET/CT) is the gold standard imaging modality to noninvasively assess vascular inflammation. Our aim was to explore a) whether MS patients (pts) have increased aortic wall inflammation as assessed by 18F-FDG PET/CT, and b) any relationship between aortic wall inflammation with serum levels of IL-6, TGF-b and MCSF. Methods: The study population consisted of fifteen MS pts and seventeen sex and age matched controls (ctrls). In all pts and ctrls we measured serum levels of circulating IL-6, TGF-b and MCSF. In PET/CT, the arterial target-to-background ratio (TBR) was calculated for aortic root (AR), ascendi
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- Author
- Styliani V. Brili; Viktor Gkotzamanis; Pavlos Kafouris; Vasiliki-Chara Mystakidi; Athanasios Sakalidis; Alexis S. Antonopoulos; Evangelos Oikonomou; Constantinos Anagnostopoulos; Konstantinos Tsioufis
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)