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First-line Drugs Inhibiting the Renin Angiotensin System Versus Other First-line Antihypertensive Drug Classes for Hypertension by Yu Jie Chen; Liang Jin Li; Wen Lu Tang; Jia Yang Song; Ru Qiu; Qian Li; Hao Xue; James M Wright is a Medicine article available to read on EtoBox.

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## Background: This is the first update of a cochrane review first published in 2015. renin angiotensin system (ras) inhibitors include angiotensin converting enzyme (ace) inhibitors, angiotensin receptor blockers (arbs) and renin inhibitors. they are widely prescribed for treatment of hypertension, especially for people with diabetes because of postulated advantages for reducing diabetic nephropathy and cardiovascular morbidity and mortality. despite widespread use for hypertension, the efficacy and safety of ras inhibitors compared to other antihypertensive drug classes remains unclear. ## Objectives: To evaluate the benefits and harms of first-line ras inhibitors compared to other first-line antihypertensive drugs in people with hypertension. ## Search methods: The cochrane hypertension group information specialist searched the following databases for randomized controlled trials up to november 2017: the cochrane hypertension specialised register, the cochrane central register of controlled trials (central), medline (from 1946), embase (from 1974), the world health organization international clinical trials registry platform, and clinicaltrials.gov. we also contacted authors of

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Author

Yu Jie Chen; Liang Jin Li; Wen Lu Tang; Jia Yang Song; Ru Qiu; Qian Li; Hao Xue; James M Wright

Publisher

Wiley

Published

2018

Language

EN

Field

Medicine (Health Sciences)