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Dietary Sodium Restriction Alters Muscle Lipidomics That Relates to Insulin Resistance in Mice by Paula Ramos Pinto; Marcos Y. Yoshinaga; Vanessa Del Bianco; Ana Paula Bochi; Guilherme S. Ferreira; Isabella F.D. Pinto; Letícia G. Rodrigues; Edna R. Nakandakare; Maristela M. Okamoto; Ubiratan F. Machado; Sayuri Miyamoto; Sergio Catanozi; Marisa Passarelli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Dietary Sodium Restriction Alters Muscle Lipidomics That Relates to Insulin Resistance in Mice about?
A low-sodium (LS) diet has been shown to reduce blood pressure (BP) and the incidence of cardiovascular diseases. However, severe dietary sodium restriction promotes insulin resistance (IR) and dyslipidemia in animal models and humans. Thus, further clarification of the long-term consequences of LS is needed. Here, we investigated the effects of chronic LS on gastrocnemius gene and protein expression and lipidomics and its association with IR and plasma lipids in LDL receptor knockout mice. Three-month-old male mice were fed a normal sodium diet (NS; 0.5% Na; n = 12-19) or LS (0.06% Na; n = 14-20) over 90 days. Body mass (BM), BP, plasma total cholesterol, triacylglycerol (TG), glucose, hematocrit, and IR were evaluated. LS increased BM (9%), plasma TG (51%), blood glucose (19%), and IR (46%) when compared with the NS. RT-qPCR analysis revealed that genes involved in lipid uptake and oxidation were increased by the LS: Fabp3 (106%), Prkaa1 (46%), and Cpt1 (74%). Genes and proteins (assessed by Western blotting) involved in insulin signaling were not changed by the LS. Similarly, lipid species classically involved in muscle IR, such as diacylglycerols and ceramides detected by ultra
Who reads Dietary Sodium Restriction Alters Muscle Lipidomics That Relates to Insulin Resistance in Mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Paula Ramos Pinto; Marcos Y. Yoshinaga; Vanessa Del Bianco; Ana Paula Bochi; Guilherme S. Ferreira; Isabella F.D. Pinto; Letícia G. Rodrigues; Edna R. Nakandakare; Maristela M. Okamoto; Ubiratan F. Machado; Sayuri Miyamoto; Sergio Catanozi; Marisa Passarelli
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)