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G Protein-coupled Receptors : Structure, Signaling, and Physiology by Sandra Siehler, Graeme Milligan,Cambridge University Press, Sandra Siehler, Graeme Milligan is a book available to read on EtoBox.

What is G Protein-coupled Receptors : Structure, Signaling, and Physiology about?

"This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The first chapters of this book illustrate the history of GPCRs based on distinct species and genomic information. This is followed by discussion of the homo- and hetero-oligomerization features of GPCRs, including receptors for glutamate, GABAB, dopamine, and chemokines. Several chapters aredevoted to the key signaling features of GPCRs. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically -adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis"--Provided by publisher. \"This text provides a comprehensive overview of r

Author

Sandra Siehler, Graeme Milligan,Cambridge University Press, Sandra Siehler, Graeme Milligan

Publisher

Cambridge University Press (Virtual Publishing)

Published

2011

Language

EN

ISBN

9780511909160

Subjects

Science, Chemistry, Medical