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Down syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21. It is associated with intellectual disabilities and characteristic physical features. Approximately 6,000 babies are born with Down syndrome each year in the United States. The risk of having a baby with Down syndrome increases significantly with the age of the mother, from 1 in 1,300 at age 25 to 1 in 25 at age 49. Most cases of Down syndrome occur randomly during egg or sperm formation

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