Can I read From the Metabolic Profiling of Drug Response to Drug Mode of Action on EtoBox?

From the Metabolic Profiling of Drug Response to Drug Mode of Action by Zampieri, Mattia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is From the Metabolic Profiling of Drug Response to Drug Mode of Action about?

One major bottleneck in the discovery and development of novel drug candidates is the identification of mechanisms of drug action. Extracting molecular signatures of drug action using functional genomic approaches, such as transcriptomics or proteomics, has become an invaluable tool to resolve drug cellular targets and downstream effects using comparative analysis and network-based approaches. The unprecedented sensitivity and throughput of recent metabolomics platforms make metabolic drug profiling an emerging and particularly promising rapid screening approach to aid and guide drug discovery. While metabolite concentrations provide biochemical signatures for monitoring the physiological effects of drugs and investigate their efficacy, selectivity, and toxicity, the application of metabolomics to predict drug Modes of Action (MoA) is still largely underexplored. This review surveys recent studies demonstrating the applicability of metabolomics to aid the systematic prediction of drug MoAs, and discusses how the emergence of large-scale metabolomics data provides new opportunities for lead selection and development at early stages of drug discovery. ## Highlights: • Drug-induced me

Who reads From the Metabolic Profiling of Drug Response to Drug Mode of Action?

Author

Zampieri, Mattia

Publisher

Elsevier ; Elsevier Ltd; Elsevier BV (ISSN 2452-3100)

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)